March Madness betting will open with Kansas as the top seed in the Midwest regional and a heavy bet on March Madness favorite to make the Final Four. The Jayhawks will be an overwhelming March Madness betting favorite against Lehigh in the opening round on March 18. They will face the winner of the 8-seeded UNLV and 9-seeded Northern Iowa matchup.
The two-seed in the Midwest are the Ohio State Buckeyes, who will face the 15-seed UC Santa Barbara Gauchos.
The winner of that March Madness betting matchup will take on the winner of the March Madness betting matchup between 7-seed Oklahoma State and 10-seed Georgia Tech.
3-seed Georgetown will take on 14-seed Ohio with the winner taking on the winner of the March Madness betting line matchup between 6-seed Tennessee and 11-seed San Diego State. 5-seed Michigan State will take on 12-seed New Mexico State.
The winner will take on the March Madness betting matchup survivor between 4-seed Maryland and 13-seed Houston. There are several outstanding “sleeper” candidates in the Midwest as San Diego State finished very strong down the stretch in winning the Mountain West Conference.
Maryland was also strong as they beat Duke at the end of the March Madness betting regular season to take a share of the Atlantic Coast Conference title. Ohio State was another impressive team that closed well as they tied for the regular season Big Ten Conference title and then won the post season conference tournament.
The Buckeyes are peaking at the right time and are a team that nobody wants to play. Kansas was the dominant team in the Big 12 as they were both the regular season and conference tournament champions.
Tennessee has plenty of tournament experience but was inconsistent this year and not likely to maintain their success and expectations of the past. Michigan State showed the potential early in the season to be able to beat anyone at any time and was a heavy Big Ten chalk but they had a horrible closing stretch that has lessened their overall appeal.