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NFL Betting: New England Patriots vs. San Francisco 49ers

NFL betting fans will get another chance to boost their bankrolls on Sunday when the Patriots (2-1, 1-2 ATS) battle with the 49ers (2-2, 2-2 ATS).

Kickoff from San Francisco is set for 4:15 ET. These two teams last hooked up in 2005 in a game that saw New England win 21-7 as 13-point home favorites. Football betting fans will get their first look at the Pats this weekend since they shockingly got rolled up and smoked by the Dolphins, 38-13, as 12.5-point Gillette Stadium favorites per the closing NFL betting line.

After Tom Brady and Randy Moss combined to shatter almost every passing and receiving record in the books last year, New England only has two passing touchdowns as a team in ’08. They’ve been poison of late for their bettors, as the Patriots are just 1-9 ATS in their L/10 games overall.

However, when the oddsmakers have installed them as less than double digit favorites, New England is on a 15-4 ATS run. The 49ers spent Week 4 in the Bayou taking on the Saints. With New Orleans battling a ton of injuries, the football betting odds featured the Niners as four-point road underdogs, but it wasn’t nearly enough for their NFL betting backers.

QB JT O’Sullivan chucked two INTs and only completed 50% of his passes throughout the game. The defense didn’t fare much better, giving up a gargantuan 363 passing yards to Drew Brees, part of the 467 total yards that the 49ers defense surrendered overall throughout the contest.

When it was all said and done, SF dropped its second game of the season by a 31-17 final count. Oddsmakers are banking on a better performance from the Niners, as they have been installed as slim 3.5-point home underdogs against the mighty Patriots. The ‘total’ has dropped from 42.5 to as low as 41 in some sportsbooks, and currently sits at 41.5.

Consider adding the ‘under’ to your NFL betting card this weekend since five of the previous six meetings between these teams have been of the lower scoring variety. Sports-Gambling.com Sportsbook has all of the football betting you can sink your teeth into.

So open an account today and get your NFL bets in for this and all of the other great betting match-ups Week 5 has to offer.