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Football Betting: San Francisco 49ers vs. Buffalo Bills

Football betting on Sunday features a must win game as the Bills host the 49ers in a pro football betting matchup of contender versus spoiler.

Football betting on San Francisco has not been for the faint of heart this season.  The 49ers have a pro football betting record of 3-8 straight up and 4-7 against the football betting lines.  San Francisco has an over/under football betting record of 7-4 over the total.

In road football betting action San Francisco is 2-3 against the spread.  San Francisco has been on a poor football betting streak in which they have covered the spread in just 2 of their last 5 games.  Last week San Francisco suffered a football betting loss at Dallas 22-35 as 9.5-point dogs.

The game went over the total and extends a football betting streak for the 49ers of 4 straight games over the total.  They are ranked 18th overall on offense while ranking 29th on defense.  The Buffalo Bills saved their season last week at Kansas City as they earned a pro football betting win of 54-31 as 3-point chalks.

Overall Buffalo has a football betting record of 6-5 straight up and 5-6 against the football betting lines.  Buffalo had suffered a football betting loss streak of 4 straight games before the win over the Chiefs, which got them back into playoff contention.

Buffalo has a football betting home record of 2-3 against the spread and an over/under football betting mark of 6-4-1 over the total.  The Bills are ranked 8th overall on offense while ranking 20th overall on defense.

San Francisco has had a problem getting the cash in road action dating back to last season as they have beat the spread in just 3 of their last 12 games away from home.  Buffalo has beaten the spread in 4 of their last 5 head to head matchups with San Francisco.  The Bills have covered 12 of their last 18 home games against the spread.

Buffalo has gone over the total in 7 of their last 9 home games.

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